Preventing the Development of Chronic Pain: Treating PTSD at Acute Pain Onset

Status: Recruiting
Location: See location...
Intervention Type: Behavioral, Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Although most people recover from acute pain (such as pain caused by injury, surgery, repetitive motion, or unknown causes), many people do not fully recover and will experience chronic pain. Untreated posttraumatic stress disorder (PTSD) appears to be a key risk factor for the transition from acute pain to chronic pain. However, few published studies have addressed the issue of preventing the transition from acute to chronic pain via PTSD reduction. This project will aim to test whether trauma-related PTSD symptoms can be reduced using either Stellate Ganglion Block (SGB) treatment or Cognitive Processing Therapy (CPT), and whether reducing PTSD symptoms can prevent the transition from non-injury based acute pain to chronic pain.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: f
View:

• Age 18 to 70 years

• Ability to read and write English sufficiently to understand and complete study questionnaires and participate in interviews

• Presenting to the Rush ED with acute pain without debilitating trauma

• A primary acute pain site

• Self-reported symptoms consistent with a diagnosis of PTSD

• People with well-controlled diabetes or HIV/AIDS with chronic neuropathic pain will be included if their acute pain complaint at ED presentation is not due to neuropathic pain

• Individuals with a history of psychotic or bipolar disorder that is currently well managed, have been treated for the condition for at least 3 months, are able to coherently answer interview questions, and are judged by study staff to be capable of participating in study

• Current chronic illness that involves constant or frequent pain if their acute pain complaint at ED presentation is not due to the chronic illness. (case-by-case basis)

• Current chronic pain from various sources if their acute pain complaint at ED presentation is not related to their current chronic pain. (case-by-case basis)

Locations
United States
Illinois
Rush University Medical Center
RECRUITING
Chicago
Contact Information
Primary
John W Burns, PhD
john_burns@rush.edu
312-942-0379
Time Frame
Start Date: 2023-09-01
Estimated Completion Date: 2027-02-01
Participants
Target number of participants: 345
Treatments
Active_comparator: Stellate Ganglion Block Treatment
Participants randomly assigned to the Stellate Ganglion Block (SGB) condition will receive 2 SGB treatments separated by 2 weeks.
Active_comparator: Cognitive Processing Therapy
Participants randomly assigned to the Cognitive Processing Therapy (CPT) condition will receive 1-week massed CPT treatment consisting of 10 CPT sessions given within a single 5-day period via telehealth.
No_intervention: Usual Care
Participants randomly assigned to the Usual Care condition will not receive any active intervention.
Sponsors
Collaborators: United States Department of Defense
Leads: Rush University Medical Center

This content was sourced from clinicaltrials.gov